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Low Dose Naltrexone Forum :: General :: LOW DOSE NALTREXONE DISCUSSION FORUM--Main Board :: DLPA

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Topic: DLPA (Read 1,092 times)

j100x
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DLPA
« Thread Started on Sept 11, 2010, 11:39pm »

I'm trying to amass some info first before starting on LDN.
I actually have controlled hypertension and I've heard DLPA is contraindicated for those with this condition.

Can anyone point me out to the research/study that shows this effect of DLPA by posting a link. I've tried googling and checking PUBMED but can't find the study.

Logically I wonder why DLPA could cause high blood pressure. I'm not refuting it, just trying to understand.

Could it be that Phenylalanine converts to Tyrosine which then converts to Dopamine that's the issue? Dopamine does cause rise in bp. But dopamine is essential , ie, you cannot not have it.

Could it be that DLPA causes excess dopamine to form? If that were the case it would become a Parkinson's drug candidate.

Also would a single tablet of DLPA say 500mg be of any use?

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Brenda
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Re: DLPA
« Reply #1 on Sept 12, 2010, 10:54am »

Probably nothing below will be what you're searching for.

DL-Phenylalanine and pain control

This is a combination of the D and L form of the amino acid phenylalanine.

This form of phenylalanine acts as a natural pain-reliever. DL-phenylalanine blocks the enzymes responsible for the breakdown of endorphins and enkephlins. Endorphins and enkephlins are a group of substances within the body that help relieve pain. Endorphins are actually far more powerful than the drug known as morphine. Small cells throughout the nervous system, brain, spinal cord, and nerve endings are able to produce these morphine-like proteins. It acts as an appetite suppressant and mild stimulant. Although caution is advised for individuals with high blood pressure, DL-phenylalanine is an affective supplement in treating musculoskeletal pains, including those associated with FMS. Many of my Fibromyalgia and chronic pain patients have benefited from taking DL-Phenylalanine. A clinical study shows subjects taking DL-phenylalanine had a remarkable improvement in their condition. Improvements were seen in 73 percent of low back pain suffers, 67 percent with migraines, 81 percent with osteoarthritis, and 81 percent with rheumatoid arthritis according to J. Brawly, pg. 131, The Food Allergy Revolution. For pain control, or as an antidepressant, take 1,000-4,000 mg twice a day on an empty stomach. Phenylalanine can elevate blood pressure and very high doses can cause rapid heart beat. Start with a low dose and increase to higher doses only as needed–and only if no side effects are noticed.

http://www.drrodger.com/newsletters_letters/letterseptember.html

http://www.wholehealthmd.com/ME2/dirmod.....EADB&tier=2#pos

Phenylalanine is an essential amino acid (a building block for proteins in the body), meaning the body needs it for health but cannot make it. You have to get it from food. Phenylalanine is found in three forms: L-phenylalanine, the natural form found in proteins; D-phenylalanine (a mirror image of L-phenylalanine that is made in a laboratory), and DL-phenylalanine, a combination of the two forms.

The body changes phenylalanine into tyrosine, another amino acid that's needed to make proteins, brain chemicals including L-dopa, epinephrine, and norepinephrine, and thyroid hormones. Because norepinephrine affects mood, different forms of phenylalanine have been proposed to treat depression.

you may find some answers to this within some of these studies. finding studies that showed DLPA affecting those with high BP might be like looking for a needle in a haystack as most studies of DLPA were done on other diseases, not high BP. I do remember someone on this forum trying DLPA and it caused his BP to rise so he had to give up the DLPA, think it was someone with psoriasis.

View clinical references for this vitamin or supplement
References:

Antoniou C, Schulpis H, Michas T, et al. Vitiligo therapy with oral and topical phenylalanine with UVA exposure. Int J Dermatol 1989;28:545-7.

Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.

Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37.

Beckmann H, Athen D, Olteanu M, Zimmer R. DL-phenylalanine versus imipramine: a double-blind controlled study. Arch Psychiatr Nervenkr 1979;227:49-58.

Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7.

Bornstein RA, Baker GB, Carroll A, et al. Plasma amino acids in attention deficit disorder. Psychiatry Res 1990;33:301-6.

Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6.

Cormane RH, Siddiqui AH, Westerhof W, Schutgens RB. Phenylalanine and UVA light for the treatment of vitiligo. Arch Dermatol Res 1985;277:126-30.

Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of parkinsonism. N Engl J Med 1967;276:374-9.

Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.nap.edu/books/0309085373/html/.

Gardos G, Cole JO, Matthews JD, et al. The acute effects of a loading dose of phenylalanine in unipolar depressed patients with and without tardive dyskinesia. Neuropsychopharmacology 1992;6:241-7.

Heller B, Fischer BE, Martin R. Therapeutic action of D-phenylalanine in Parkinson's disease. Arzneimittelforschung 1976;26:577-9.

Jardim LB, Palma-Dias R, Silva LC, et al. Maternal hyperphenylalaninaemia as a cause of microcephaly and mental retardation. Acta Paediatr 1996;85:943-6.

Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5.

Kitade T, Odahara Y, Shinohara S, et al. Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (2nd report)- schedule of administration and clinical effects in low back pain and tooth extraction. Acupunct Electrother Res 1990;15:121-35.

Kuiters GR, et al. Oral phenylalanine loading and sunlight as source of UVA irradiation in vitiligo on the Caribbean island of Curacao NA. J Trop Med Hyg 1986;89:149-55.

Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128:181-98.

Mitchell MJ, Daines GE, Thomas BL. Effect of L-tryptophan and phenylalanine on burning pain threshold. Phys Ther 1987;67:203-5.

Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46.

National Institutes of Health Consensus Development Conference Statement. Phenylketonuria: Screening and Management http://odp.od.nih.gov/consensus/cons/113/113_statement.htm (Accessed 15 August 2003).

Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8.

PKU - Dietary Treatment of the Untreated Adult PKU. National Society for Phenylketonuria (NSPKU). 1996-2001. Available at: web.ukonline.co.uk/nspku/untreatd.htm

Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95.

Schulpis CH, Antoniou C, Michas T, Strarigos J. Phenylalanine plus ultraviolet light: preliminary report of a promising treatment for childhood vitiligo. Pediatr Dermatol 1989;6:332-5.

Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8.

Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.

Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.

Thiele B, Steigleder GK. [Repigmentation treatment of vitiligo with L-phenylalanine and UVA irradiation]. [Article in German]. Z Hautkr 1987;62:519-23.

Walsh NE, Ramamurthy S, Schoenfeld L, Hoffman J. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil 1986;67:436-9.

Wilson CJ, Van Wyk KG, Leonard JV, Clayton PT. Phenylalanine supplementation improves the phenylalanine profile in tyrosinaemia. J Inherit Metab Dis. 2000;23:677-83.

Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.

Zametkin AJ, Karoum F, Rapoport JL. Treatment of hyperactive children with D-phenylalanine. Am J Psychiatry 1987;144:792-4.

Zhao G. [Inherited metabolic aberration of phenylalanine in the family members of patients with essential hypertension and stroke]. [Article in Chinese]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:28, 388-90.

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j100x
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Re: DLPA
« Reply #2 on Sept 13, 2010, 9:50am »

It indeed is a tough search.

1. Here's an interesting article by the U of Maryland, which talks of some possible interactions with DLPA.

[url]http://www.umm.edu/altmed/articles/phenylalanine-000318.htm[/url]

It does say that DLPA with MOAI can be dangerous with regard to blood pressure.

2. I get the impression that the L isomer of DLPA is the bp suspect. There are some companies now which sell just D-Phenylalanine.

Brenda,
Any thoughts regarding D-phenylalanine?

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j100x
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Re: DLPA
« Reply #3 on Sept 13, 2010, 9:52am »

I didn't get the url right.
try this:
http://www.umm.edu/altmed/articles/phenylalanine-000318.htm

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Brenda
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Re: DLPA
« Reply #4 on Sept 13, 2010, 10:42am »

I think the D by itself is safer for those with high BP than the DL combo. You might try it at a lower dosage and see how it affects your BP and if none at all then up it to normal recommended dose and see what happens. If a negative reaction occurs, then come off it.

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