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Joined: Mar 2004 Gender: Female Posts: 5,129 Location: Mid-South USA
Dr McCandless, seldom is LDN stand-alone treatment « Thread Started on Apr 6, 2009, 4:24pm »
As usual, I need to emphasize that seldom is LDN a stand-alone treatment, but accompanies other strategies their body needs, especially a healthy diet. No sugar, dairy or gluten.
If you are having adverse symptoms caused by LDN....
Would you be willing to stop all casein (milk products) and gluten (wheat, rye, barley and oats) for a week and see if you feel better? A study done several years ago showed that 30% of us have some degree of celiac disease(intolerance/allegy to wheat) even though the clinical symptoms may not be obvious enough to alert most people to that. When anyone in that 30% of persons stops eating wheat, they feel a lot better. The LDN may be acting like the opioid antagonist it is and causing a withdrawal reaction from taking away your fix, even if only for a few hours.
JAQUELYN MCCANDLESS <JMcCandless@...> wrote:
Celiac disease (allergy to gluten protein) which most people do not know does not come in an "all or none" fashion; there are many degrees of celiac intolerance. Untold numbers of people eat wheat since it is a staple food in our society and never feel good - they have indigestion, stool irregularities, weight issues, depression and never know that if they would eliminate wheat and casein they would feel like new people. Many people who eat wheat and milk do not even know what "feeling good" is like until they remove these foods from their diet. As I have said many times before on this board, anytime someone has a negative reaction to LDN the first question I would ask is, "What is the diet like?" If I had a disease such as ALS or MS or other autoimmune disease, I would be more than willing to see if my dietary exogenous opioids could be causing the negative reaction to a drug that is helping most of these people get off all their other drugs without progression of their disease. The reason this is a worthwhile trial is that this intolerance is affecting their general health and immunity in a negative way. Unfortunately, sometimes it takes up to 6 months to get gluten out of the system, so it is not so easy to test. Food is so emotionally entrenched in most people's notions of love and inner security, you would be amazed at what people will endure to eat the foods to which they are addicted! I have a huge respect for the power of addiction to foods and the difficulty in making radical changes from the diet we are accustomed to. Usually it takes an evaluation in the context of a serious illness for people to even consider changing, and even then many will not. Dr. JM
It takes some people longer to respond to LDN, and they may be colonized with pathogenic yeast and bacteria that could be slowing response.
These setbacks usually do not last long unless something like a yeast infection is stubborn without specific treatment.
Dr. JM
MORE BELOW
There is a phenomenon that happens to some people that as the immune system is shifting (usually from T2 to T1) right after starting LDN, the immune system drops and people get an infection, cold, flu, cold sore, etc. which is usually short lived. Candida tends to overgrow or a virus will flare up. These infections are usually short-lived unless something like candida and gut bacteria needs treatment.
As usual, I need to emphasize that seldom is LDN a stand-alone treatment, but accompanies other strategies their body needs, especially a healthy diet.
Are you a big bread/carbohydrate/sugar eater? Ever been tested for candida (yeast) or gut bacterial infestation? Ever been checked for hypothyroidism?
Would you be willing to stop all casein (milk products) and gluten (wheat, rye, barley and oats) for a week and see if you feel better? A study done several years ago showed that 30% of us have some degree of celiac disease (intolerance/allegy to wheat) even though the clinical symptoms may not be obvious enough to alert most people to that. When anyone in that 30% of persons stops eating wheat, they feel a lot better. The LDN may be acting like the opioid antagonist it is and causing a withdrawal reaction from taking away your fix, even if only for a few hours.
Try to hang in for awhile longer, and it will probably get better. These setbacks usually do not last long unless something like a yeast infection is stubborn without specific treatment. Dr. JM
Q: Dr. JM or anyone- Does LDN cause candida?
A: LDN has been noted to aggravate yeast infections and other latent pathogens, viruses, etc. as the immune system is making early adjustments. It is good to have natural yeast remedies on board when LDN is started (grapefruit seed extract, Candex, lauricidin, hi-potency probiotics, etc) to help offset this possibility. (And of course a good dietary regime that does not encourage gut inflammation which is usually the predecessor to pathogen invasion).
Dr. Jaquelyn McCandless
posted by Brenda
MORE BELOW The following is the response to a question posted to Dr. McCandless about goat milk as a substitute for cow's milk when on LDN:
"There are many, many people who take LDN who are not on a dairy-free diet, and my estimate is that about 15% need to be. Undoubtedly goat milk is healthier and easier to digest than cow's milk, but if one truly is sensitive to casein, goat milk and all animal milks except camel do have casein. Since I specialize in children with autism, who in my practice are all required to be casein/gluten free, in my studies using autistic children I never had negative reactions to LDN. When it started being used outside the autism population, I discovered that about 15% of people using it who were not on a restricted diet had hyperactivity and a negative response to LDN. I suggested they go to a low dose and work up slowly, and if that did not help, then to get off foods with the large peptides (casein, gluten & soy) that can go to the brain and act as gluteo or caseo corticoids. With those people, LDN cuts off their "fix" (these foods are actually addictions to some people) for a long enough time that they experience negative reactions, just as drug addicts do when they are given full-dose naltrexone. Very often removal of those foods made LDN as it is with most people; no adverse reactions. Again, not 100%, which we do not understand, but almost. One exception was a child who had many severe IgE allergies - nothing eventually helped her tolerate LDN and she had to stop. My suggestion to you would be to try it with goat's milk and see if you are one of the ones who cannot tolerate it; if so, then you have to decide whether milk is that important to you. You are free to give this information to anyone who is interested." Dr. JM
Dr JM responded on the LDN-Autism yahoo forum recently regarding anxiety as a side-effect of LDN. She said that about 30% of the population has celiac disease to some degree, and that celiac is not an all or nothing thing. Therefore, she postulates that, like with autistic kids, there is something going on in the gut with many of us. This would be an allergic response to gluten (in wheat and, I think, rye barley, oats) and possibly casein (milk protein) in the gut and an incomplete digestion of these proteins. The result is a release of semi-digested food polypeptides into the blood and brain, where they don't belong, and which act as opiates--they stimulate the autistic kids to act out or to space out! The autistic kids, and the rest of us who have some degree of allergy to gluten and/or casein, are "high" on these incompletely digested molecules. When LDN comes along in the blood stream and blocks the opiate effect, we get anxious.
So Dr JM absolutely recommends addressing diet first with autistic kids, but also with others who have problems acclimating to LDN.
MORE BELOW
The only way to know for sure if you have candida yeast overgrowth is to get a urinary dysbiosis test (measures by-products of yeast in the urine) - stool tests can often miss yeast, but the urine will show it. This is part of the Organic Acid Test (OAT) and is done by Metametrix, Great Plains, and Genova Labs - it must be ordered by a physician. The entire OAT (metametrix calls it Organix) tells you what vitamins you are missing and is a very good guage of your overall metabolic process, including toxicities and deficiencies. The dysbiosis part only measure the by-products of yeast and bacteria, and does not cost as much as the full test. This is one of the routine tests I get on all children with autism, as they have many metabolic disorders and most have yeast and bacteria and need to be treated for this to help them improve their health.
Dr. JM
Any licensed physician can open up an account at Metametrix (www.metametrix.com) and order the organic acid test (OAT) kits to be sent to their clients to their home, he/she supplies a first morning urine to place in the test tube in the kit and mails that back to the lab which analyzes the results and sends them to your doctor. The retail cost is $538 but if you send your check or credit card in with the urine sample that is called "rapid pay" (they don't have to try to get insurance to pay, which unfortunately very seldom does for these specialty tests) and costs $323. It is an excellent test for showing what kind of vitamins you need, where your shortages are, and whether you have bacteria or yeast in your GI tract. To get sensitivities so you know what kind of anti-fungals or anti-bacterials you need, a comprehensive stool test is necessary, and I use Doctor's Data for that - (www.doctorsdata.com), this test costs $235 (also for "rapid pay"). This is also a kit that the lab sends to you and you mail it back with your sample and payment. Hope this helps. Dr. Jaquelyn McCandless
Joined: Mar 2004 Gender: Female Posts: 5,129 Location: Mid-South USA
Re: Dr McCandless, seldom is LDN stand-alone treat « Reply #1 on May 17, 2009, 9:51pm »
Q: Dr. JM or anyone- Does LDN cause candida?
A: LDN has been noted to aggravate yeast infections and other latent pathogens, viruses, etc. as the immune system is making early adjustments. It is good to have natural yeast remedies on board when LDN is started (grapefruit seed extract, Candex, lauricidin, hi-potency probiotics, etc) to help offset this possibility. (And of course a good dietary regime that does not encourage gut inflammation which is usually the predecessor to pathogen invasion). Dr. Jaquelyn McCandless
Joined: Mar 2004 Gender: Female Posts: 5,129 Location: Mid-South USA
Re: Dr McCandless, seldom is LDN stand-alone treat « Reply #2 on Nov 19, 2009, 2:05pm »
Dr. Jaquelyn McCandless' Prescription Treatment for Candida and fruits allowed with an anti-candida diet
Below by Dr. Jaquelyn McCandless, Board Certified Neurologist
Below is for adults 100 pounds(45.3kg) and over
Have you had any testing to show evidence that you do indeed have candida? (A comprehensive stool test at Doctors Data Lab is my favorite way to find out). And did you have sensitivity testing to show what kind of yeast you do have (there are many) and what anti-fungal is specified for it? When people have inflamed guts and pathogen invasion, they almost always have both bacteria and yeast at the same time. I always treat for both the bacteria (usually flagyl, 500mg 3X a day or 750mg twice a day - 10 days on with 4 days off to let spores hatch out - then 10 more days) and the yeast simultaneously (usually diflucan 200mg twice daily for three weeks) which does help 85% of cases plus copious good hi-potency probiotics to populate the gut with beneficial bacteria to prevent a yo-yo effect. When yeast die off there is more food for the pathogenic bacteria (the even eat the dead yeast!) so then the bacteria proliferate, and vice versa. A white tongue (and sore throat) almost always means yeast to me, so that would indicate you are not getting the right anti-fungal as the flagyl is killing off the bacteria leaving more food for the yeast, which are proliferating, and you are either not getting the proper anti-fungal or an adequate dose to kill the yeast.
Most ADULTS need 200mg of diflucan twice daily (I give it for 3 weeks) and 500mg of metronidazole (flagyl) 3 times a day or 750mg twice daily for 10 days, stop for 4 days to let spores hatch out, then 10 more days, plus copious hi-potency probiotics. Incidentally, I gave up nystatin years ago, as it is only a topical and does not address the colonized yeast, and the yeast outsmart it by mutating very quickly.
See bottom of this post to see the fruits allowed.
Dr. JM
Below, for adults and children UNDER 100pounds(45.3kg)
Dr. McCandless' protocol for those with insurance is diflucan (fluconazole) 100mg twice daily for three weeks, along with flagyl (metronidazole) 500mg twice a day for 10 days, stop 4 days (to let the spores hatch out) then 10 more days. Highly recommend you take good hi-potency probiotics to replace the gut with good bugs - these are never prescribed, but so necessary for all of us for good gut health. Be sure to keep the probiotics and the metronidazole 2 hours apart, as the probiotics (good bugs) will be destroyed by the metronidazole.
For both children and adults I'm sure no need to mention eliminate ALL refined sugar (if you love it, it is your yeast screaming, "SUGAR, SUGAR, SUGAR!!!". Even too much fruit sugar is bad, especially strawberries, watermelon, pineapple, and ripe bananas, and no apple or grape products, as yeast love these fruits.
Acceptable fruits are kiwi, pears, and berries in season except for strawberries. Best wishes, Dr. JM (feel free to share this for those who need prescription strength yeast treatment).
Joined: Mar 2004 Gender: Female Posts: 5,129 Location: Mid-South USA
Re: Dr McCandless, seldom is LDN stand-alone treat « Reply #3 on Sept 1, 2010, 11:41pm »
Vitamin B3(nicotinamide) as a Novel Approach to Treat Fungal Infections
A team of scientists from the Institute for Research in Immunology and Cancer of the University of Montreal have identified vitamin B3 as a potential antifungal treatment. (Credit: Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal)ScienceDaily (Aug. 10, 2010) — A team of scientists from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have identified vitamin B3(nicotinamide) as a potential antifungal treatment.
Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine.
Infections by the yeast Candida albicans represent a significant public health problem and a common complication in immunodeficient individuals such as AIDS patients, cancer patients undergoing chemotherapy and recipients of organ transplants. While some treatments are available, their efficacy can be compromised by the emergence of drug-resistant strains.
The current study shows that a Candida albicans(C. albicans) enzyme, known as Hst3, is essential to the growth and survival of the yeast. Researchers found that genetic or pharmacological inhibition of Hst3 with nicotinamide(a form of vitamin B3), strongly reduced C. albicans virulence in a mouse model. Both normal and drug-resistant strains of C. albicans were susceptible to nicotinamide. In addition, nicotinamide prevented the growth of other pathogenic Candida species and Aspergillus fumigatus (another human pathogen), thus demonstrating the broad antifungal properties of nicotinamide.
"There is an urgent need to develop new therapies to kill C. albicans because it is one of the leading causes of hospital-acquired infections and is associated with high mortality rates," explains Martine Raymond, who is also a professor at the University of Montreal Department of Biochemistry. "Although many issues remain to be investigated, the results of our study are very exciting and they constitute an important first step in the development of new therapeutic agents to treat fungal infections without major side effects for patients."
Martine Raymond is Principal Investigator in the Yeast Molecular Biology Laboratory. Alain Verreault is Principal Investigator in the Chromosome Biogenesis Laboratory. Pierre Thibault is Principal Investigator in the Proteomics and Bioanalytical Mass Spectrometry Laboratory. The research received funding from the Canadian Institutes for Health Research and the National Science and Engineering Research Council of Canada.
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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of Montreal, via EurekAlert!, a service of AAAS.
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