My mother has fibromyalgia (FM) and wet macular degeneration. She has been receiving Avastin injections in her eyes for two or three years now, and has recently started taking LDN for her FM. The LDN seems to lessen her FM symptoms, and she has now taking additional supplements like whey protein, D-Ribose, and 5-HTP.
Do you know if LDN would work for age-related macular degeneration (AMD), wet version? I know that the anti-VEGF (vascular endothelial growth factor) drugs Bevacizumab (Avastin) and Lucentis are used successfully to treat wet AMD. So if LDN increases metenkaphalins (which inhibits VEGF), would it have some impact on wet AMD? Would it be safe to take LDN while still receiving an injection of Avastin every six months?
Since FM and AMD may have a hereditary component, could LDN be taken as a preventative measure (similar to taking LDN as a preventative measure in cases where there is a family history of certain cancers)?
There are some studies and a couple of webs sites that suggest AMD has an autoimmune component.
With respect to many autoimmune diseases, I find certain terms popping up over and over in pubmed articles: VEGF, inflammation, angiogenesis, tnf....
One article I found states that recent literature links inflammatory mediators with angiogenesis through the upregulation of VEGF, while the reverse is also true. VEGF influences the inflammatory process. For example, VEGF plays a role in rheumatoid arthritis and in T-cell–mediated immunity.
According to Mary Bradley's web site, Metenkephalin/Opioid Growth Factor (OGF) is the end result of the LDN research to date. With LDN, we are increasing the body's own OGF.
Metenkaphalin is a VEGF antagonist which explains one part of how LDN works. I know that Dr. Zagon has published numerous articles that deal with OGF/metenkaphalin. This is a very exciting area of study, but sometimes the technical language is a bit difficult to follow.