In regard to daytime dosing, of all the clinical trials of LDN conducted with humans, only one used daytime dosing--a German study with a group of MS patients. While about a third of the group did experience limited benefit, this is the comment made about the trial by Dr. David Gluck, webmaster of http://ldninfo.org: Unfortunately, because of some early complaints of sleep disturbance, the principal investigator of this trial switched all of the study group to taking LDN at 9 am in the morning, a questionable dosage time. It is generally recognized that the most effective time to take LDN is at bedtime, between 9 pm and 3 am, due to the fact that the endorphins for each day are always produced at their peak rate in the pre-dawn hours. A 9 am dosage time, as was used in this trial, might conceivably suppress—rather than boost—a patient's immune system. Low Dose Naltrexone (LDN): The German MS Study www.webspawner.com/users/germanldnstudy/index.html And also note that this study was not conducted to see if LDN would halt any disease progression of any type of MS, the study was way too short for that, 10 days. I think it was basically to look at symptom improvement on only 3mg LDN. -- Here is a comment on the day/night LDN dosing by a very credible LDN Pharmacist, Skip Lenz...please read the entire comment as the two cycles he mentions pack different punch levels.
I really hate to get involved with this question, and the he said,he said responses. Who is right, Zagon or Bihari, well they both are right. One has to look at the diurnal nature of endorphin secretion to understand HOW they are both right. You get your zenith peak during your normal sleep cycle. You get your penultimate peak during your wake cycle. Taking LDN prior to your zenith peak will give you more bang for your buck than prior to your wake cycle peak. Therefore you will get some increase taking LDN at times other than prior to bedtime but they will not be the most you can get. Now if you take it indiscriminately temporally, then depending of which peak is next in the cycle, you will get a fraction of the response you would get if taken at an appropriate time frame. This explains why both docs are right, for those taking it in the am, you get the PM peak to skew upwards, those taking the PM dose gets the am peak to skew upwards. Dr.Skip
People who take LDN in the morning for allergies or depression can take the risk, but people who use it for cancer, MS and other serious diseases should be careful not miss the full potential of LDN and follow the Bihari protocol of evening dosing.
I had been on night LDN for 3 yrs and decided to try day dosing as Zagon said would do the same as night. I had been in remission of progressive MS for 3 years on night dosing but within 5 days on day dosing I came out of remission and was headed back down hill. I immediately went back to night dosing and soon saw an improvement and now on night dosing have been in remission 10 years. Maybe some with other diseases or milder forms of MS might be able to take LDN in daytime.